Understanding how blood vessel diseases affect memory and thinking skills
Official title: Elucidating cerebrovascular disease pathways to cognitive decline with vascular neuroimaging
Funded at University of Wisconsin-Madison · NIH-11142202 · Data updated 2026-11-12
This study is looking at how blood flow problems in the brain might affect thinking skills in people with Alzheimer's disease, using special MRI technology to help doctors understand and improve care for dementia patients over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $640,906 |
| NIH project number | 1R01AG089562-01A1 |
| Project ID | NIH-11142202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease who also exhibit signs of cerebrovascular disease.
✕Less likely to help
Patients with cognitive decline not related to vascular issues or those without a diagnosis of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between cerebrovascular disease and cognitive decline, particularly in patients with Alzheimer's disease. By utilizing advanced 4D flow MRI technology, the study aims to identify specific vascular processes that contribute to cognitive impairment. The approach focuses on non-invasive imaging to gather detailed information about blood flow and vascular health, which may lead to better diagnoses and treatment strategies for dementia. Patients will be monitored over several years to assess changes in their cognitive function in relation to their vascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from cognitive decline related to vascular issues.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to better understand the relationship between vascular health and cognitive decline, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Rivera Rivera, Leonardo a — University of Wisconsin-Madison
- Study coordinator: Rivera Rivera, Leonardo a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.