Understanding how blood vessel changes in the ovary affect pregnancy.
Official title: Vascular remodeling in the ovary
Funded at University of Nebraska Medical Center · NIH-10724873 · Data updated 2026-11-12
This study looks at how changes in blood vessels in the ovaries affect early pregnancy, especially focusing on a structure called the corpus luteum, and it aims to understand how certain signals might lead to pregnancy loss in the first trimester, which could help improve fertility treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 4, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $153,500 |
| NIH project number | 1R03HD112585-01 |
| Project ID | NIH-10724873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 21 and older who are experiencing infertility or have had early pregnancy losses.
✕Less likely to help
Patients who are not seeking to conceive or are not affected by infertility issues may not benefit from this research.
What this research studies
This research investigates the role of blood vessel changes in the ovary, specifically focusing on the corpus luteum, which is crucial for maintaining early pregnancy. It examines how inflammatory signals and lipid mediators, particularly prostaglandin F2α, influence the health and regression of this structure. By studying the interactions between endothelial cells and steroidogenic cells, the research aims to uncover the mechanisms behind pregnancy termination during the first trimester. This could provide insights into fertility and the factors that lead to early pregnancy loss.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and early pregnancy loss.
How similar studies have gone: Previous research has shown promising results in understanding luteal function and its impact on fertility, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Davis, John S — University of Nebraska Medical Center
- Study coordinator: Davis, John S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.