Understanding how blood vessel changes in the ovary affect pregnancy.
Vascular remodeling in the ovary
['FUNDING_R03'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10724873
This study looks at how changes in blood vessels in the ovaries affect early pregnancy, especially focusing on a structure called the corpus luteum, and it aims to understand how certain signals might lead to pregnancy loss in the first trimester, which could help improve fertility treatments.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10724873 on ClinicalTrials.gov |
What this research studies
This research investigates the role of blood vessel changes in the ovary, specifically focusing on the corpus luteum, which is crucial for maintaining early pregnancy. It examines how inflammatory signals and lipid mediators, particularly prostaglandin F2α, influence the health and regression of this structure. By studying the interactions between endothelial cells and steroidogenic cells, the research aims to uncover the mechanisms behind pregnancy termination during the first trimester. This could provide insights into fertility and the factors that lead to early pregnancy loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 21 and older who are experiencing infertility or have had early pregnancy losses.
Not a fit: Patients who are not seeking to conceive or are not affected by infertility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and early pregnancy loss.
How similar studies have performed: Previous research has shown promising results in understanding luteal function and its impact on fertility, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, JOHN S — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: DAVIS, JOHN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.