Understanding how blood vessel changes contribute to pulmonary hypertension
The pathophysiology of vascular remodeling in pulmonary hypertension
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10980237
This study is looking at how a protein called BMPER affects blood vessel changes in people with pulmonary hypertension, especially those with interstitial lung disease, to find new ways to treat this serious condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10980237 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind vascular remodeling in pulmonary hypertension (PH), a serious condition that leads to increased pressure in the lungs and can result in heart failure. The study focuses on the role of bone morphogenetic protein-binding endothelial regulator (BMPER) in the development of PH, particularly in patients with interstitial lung disease (ILD). By examining how BMPER influences vascular development, the research aims to uncover new treatment strategies that specifically target the underlying causes of vascular changes in PH. Patients may be involved in the research to help identify the pathways that lead to these changes and assess potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pulmonary hypertension, especially those with interstitial lung disease.
Not a fit: Patients with pulmonary hypertension not related to interstitial lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that specifically address the vascular remodeling associated with pulmonary hypertension, improving patient outcomes.
How similar studies have performed: While there have been advancements in treating pulmonary hypertension, this specific approach targeting BMPER in the context of ILD-PH is novel and has not been extensively tested.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PI, XINCHUN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PI, XINCHUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.