Understanding how blood vessel changes contribute to pulmonary hypertension
Official title: The pathophysiology of vascular remodeling in pulmonary hypertension
Funded at Baylor College of Medicine · NIH-10980237 · Data updated 2026-11-12
This study is looking at how a protein called BMPER affects blood vessel changes in people with pulmonary hypertension, especially those with interstitial lung disease, to find new ways to treat this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $764,891 |
| NIH project number | 1R01HL169297-01A1 |
| Project ID | NIH-10980237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pulmonary hypertension, especially those with interstitial lung disease.
✕Less likely to help
Patients with pulmonary hypertension not related to interstitial lung disease may not benefit from this research.
What this research studies
This research investigates the mechanisms behind vascular remodeling in pulmonary hypertension (PH), a serious condition that leads to increased pressure in the lungs and can result in heart failure. The study focuses on the role of bone morphogenetic protein-binding endothelial regulator (BMPER) in the development of PH, particularly in patients with interstitial lung disease (ILD). By examining how BMPER influences vascular development, the research aims to uncover new treatment strategies that specifically target the underlying causes of vascular changes in PH. Patients may be involved in the research to help identify the pathways that lead to these changes and assess potential new therapies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that specifically address the vascular remodeling associated with pulmonary hypertension, improving patient outcomes.
How similar studies have gone: While there have been advancements in treating pulmonary hypertension, this specific approach targeting BMPER in the context of ILD-PH is novel and has not been extensively tested.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Pi, Xinchun — Baylor College of Medicine
- Study coordinator: Pi, Xinchun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.