Understanding how blood vessel cells produce and release important proteins for blood clotting
Official title: Molecular Mechanisms Underlying Endothelial Weibel-Palade Body Biogenesis and Exocytosis
Funded at Yale University · NIH-11091596 · Data updated 2026-11-12
This study is looking at how certain cells in your blood vessels make and release a protein called von Willebrand factor, which is important for blood clotting, to help improve our understanding of bleeding disorders and find better treatments for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $165,024 |
| NIH project number | 5K08HL150246-05 |
| Project ID | NIH-11091596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with bleeding disorders, particularly those with von Willebrand disease or related coagulation issues.
✕Less likely to help
Patients with conditions unrelated to blood coagulation or endothelial function may not benefit from this research.
What this research studies
This research investigates the molecular processes that allow endothelial cells, which line blood vessels, to produce and release von Willebrand factor (vWF), a crucial protein for blood clotting. The study focuses on the biogenesis and exocytosis of Weibel-Palade bodies, which store vWF, and aims to uncover the role of specific protein complexes in this process. By examining how these mechanisms work, the research seeks to provide insights into bleeding disorders and cardiovascular risks associated with abnormal vWF levels. Patients may benefit from a better understanding of their conditions and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bleeding disorders and cardiovascular diseases related to von Willebrand factor.
How similar studies have gone: Previous research has shown success in understanding similar molecular mechanisms related to blood coagulation, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sharda, Anish Vaibhav — Yale University
- Study coordinator: Sharda, Anish Vaibhav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.