Understanding how blood vessel cells move and interact
Regulation of endothelial cell invasion, migration and cell junction plasticity
This study is looking at how the cells that line our blood vessels move and connect with each other, which is important for forming new blood vessels, and it aims to understand how these cells react to their surroundings to keep our blood vessels healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10890106 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate how endothelial cells, which line blood vessels, migrate and form connections with each other. By focusing on the signaling pathways that control these processes, the study aims to uncover how these cells respond to their environment during events like angiogenesis, which is the formation of new blood vessels. The researchers will use advanced techniques to analyze how the timing and location of signals influence cell movement and the integrity of the endothelial barrier, which is crucial for maintaining proper vascular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve abnormal blood vessel formation or function.
Not a fit: Patients with stable vascular conditions that do not involve endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases where blood vessel function is compromised, such as cancer and cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding endothelial cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Karginov, Andrei V — University of Illinois at Chicago
- Study coordinator: Karginov, Andrei V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.