Understanding how blood vessel cells maintain balance and prevent heart disease
Mechanisms Regulating Vascular Homeostasis
This study is looking at how certain proteins help keep the cells that line our blood vessels healthy, which could lead to new treatments for heart and blood vessel problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10889198 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the function of endothelial cells, which line blood vessels and are crucial for maintaining vascular health. It focuses on the role of specific proteins, such as angiopoietins and Tie receptors, in promoting healthy blood vessel function and preventing conditions like cardiovascular disease. By exploring the interactions between these proteins and their effects on endothelial cell behavior, the research aims to uncover new insights into how blood vessels can remain stable and resist disease. Patients may benefit from findings that could lead to new treatments for cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for cardiovascular disease or those with existing vascular conditions.
Not a fit: Patients with non-vascular related health issues or those not at risk for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve vascular health and reduce the risk of cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding vascular mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kontos, Christopher D — Duke University
- Study coordinator: Kontos, Christopher D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.