Understanding how blood vessel cells interact in capillary malformations
Endothelial and mural cell interaction in capillary malformation
This study is looking at how certain blood vessel problems, called capillary malformations, affect people with Sturge Weber Syndrome, and it aims to understand how the cells that make up these blood vessels work together, which could help find new ways to treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11031307 on NIH RePORTER |
What this research studies
This research investigates capillary malformations (CM), which are enlarged blood vessels that can lead to serious health issues like seizures and strokes, particularly in patients with Sturge Weber Syndrome. The study focuses on the interactions between endothelial cells, which line the blood vessels, and mural cells that support them, especially in the context of a specific genetic mutation. By examining how these cells behave and interact, the research aims to uncover the underlying mechanisms of CM and potentially identify new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with capillary malformations, particularly those with Sturge Weber Syndrome.
Not a fit: Patients without capillary malformations or those not affected by Sturge Weber Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from capillary malformations.
How similar studies have performed: While the specific interactions being studied may be novel, previous research has shown promise in understanding vascular malformations and their genetic underpinnings.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Nasim, Sana — Boston Children's Hospital
- Study coordinator: Nasim, Sana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.