Understanding how blood vessel cells interact in capillary malformations
Official title: Endothelial and mural cell interaction in capillary malformation
Funded at Boston Children's Hospital · NIH-11031307 · Data updated 2026-11-12
This study is looking at how certain blood vessel problems, called capillary malformations, affect people with Sturge Weber Syndrome, and it aims to understand how the cells that make up these blood vessels work together, which could help find new ways to treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 2, 2023 |
| Project end | December 1, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,892 |
| NIH project number | 5F32HL172637-02 |
| Project ID | NIH-11031307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with capillary malformations, particularly those with Sturge Weber Syndrome.
✕Less likely to help
Patients without capillary malformations or those not affected by Sturge Weber Syndrome may not benefit from this research.
What this research studies
This research investigates capillary malformations (CM), which are enlarged blood vessels that can lead to serious health issues like seizures and strokes, particularly in patients with Sturge Weber Syndrome. The study focuses on the interactions between endothelial cells, which line the blood vessels, and mural cells that support them, especially in the context of a specific genetic mutation. By examining how these cells behave and interact, the research aims to uncover the underlying mechanisms of CM and potentially identify new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from capillary malformations.
How similar studies have gone: While the specific interactions being studied may be novel, previous research has shown promise in understanding vascular malformations and their genetic underpinnings.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Nasim, Sana — Boston Children's Hospital
- Study coordinator: Nasim, Sana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.