Understanding how blood vessel cells help the intestines heal and regenerate
Official title: Investigating the role of endothelial cells in intestinal regeneration and disease
Funded at Yale University · NIH-11055231 · Data updated 2026-11-12
This study is looking at how certain cells in our blood vessels help heal the intestines after injury or during conditions like inflammatory bowel disease, and it hopes to find new ways to improve treatments for people with these intestinal issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $155,443 |
| NIH project number | 1K01DK139399-01A1 |
| Project ID | NIH-11055231 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing intestinal dysfunction or inflammatory bowel disease.
✕Less likely to help
Patients with non-intestinal related conditions or those under 21 years old may not receive any benefit from this research.
What this research studies
This research investigates the role of blood vessel endothelial cells in the healing and regeneration of the intestines, particularly after injury or in conditions like inflammatory bowel disease. By using advanced techniques such as mouse models, immune profiling, and single-cell RNA sequencing, the study aims to uncover how these cells support intestinal stem cells and contribute to repair processes. Patients may benefit from insights that could lead to new treatments for intestinal dysfunction and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from intestinal diseases and improve healing after intestinal injuries.
How similar studies have gone: Other research has shown promise in understanding the role of endothelial cells in tissue regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Palikuqi, Brisa — Yale University
- Study coordinator: Palikuqi, Brisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.