Understanding how blood vessel cells contribute to disease risk
Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk
This project aims to understand how different types of blood vessel cells in the human body contribute to the risk of various diseases like heart disease, stroke, dementia, and cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11091462 on NIH RePORTER |
What this research studies
Blood vessels are found throughout your body and play a role in many health conditions. When these vessels don't work properly, it can increase your risk for problems like heart disease, stroke, dementia, and even affect how other diseases like cancer develop. Researchers are using advanced techniques to look closely at individual cells within human blood vessels. By combining this detailed cell information with genetic risk factors, we hope to pinpoint which specific blood vessel cells are involved in the early stages of disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit individuals at risk for or living with arterial diseases, dementia, cancer, and diabetes.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify people at risk for various diseases and develop more targeted treatments by understanding the root causes in blood vessel cells.
How similar studies have performed: Other research groups, including this one, have successfully used single-cell analysis to identify different types of cells within blood vessels, showing promise for this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gupta, Rajat M — Brigham and Women's Hospital
- Study coordinator: Gupta, Rajat M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.