Understanding how blood vessel cells contribute to blood clots in certain blood cancers
Engineered microsystems to assess endothelial contribution to myeloproliferative neoplasm thrombosis
This study is looking at how certain cells in your blood vessels might contribute to blood clots in people with myeloproliferative neoplasms (MPNs), especially those with a specific mutation, and it aims to understand how current medications can help, with the possibility of you providing blood samples to assist in this research.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10895325 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial cells, which line blood vessels, in the development of thrombosis (blood clots) in patients with myeloproliferative neoplasms (MPNs). The study focuses on how a specific mutation, JAK2V617F+, affects these cells and their interaction with blood components, potentially leading to increased clotting risks. By using engineered microsystems, researchers aim to better understand the mechanisms behind this process and evaluate the effects of existing medications on these cells. Patients may be involved in providing blood samples to help characterize these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms, particularly those with the JAK2V617F+ mutation.
Not a fit: Patients without myeloproliferative neoplasms or those who do not have the JAK2V617F+ mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing thrombosis in patients with myeloproliferative neoplasms.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial cells in thrombosis, suggesting that this approach may yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Beckman, Joan Denise — University of Minnesota
- Study coordinator: Beckman, Joan Denise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.