Understanding how blood vessel cells affect myelodysplastic syndromes
Official title: Defining and Manipulating the Endothelial Niche in Myelodysplastic Syndromes
Funded at University of Rochester · NIH-10850984 · Data updated 2026-11-12
This study is looking at how certain cells in your blood vessels affect the way blood-forming cells work in people with myelodysplastic syndromes, especially in older adults, to find new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $221,760 |
| NIH project number | 5R01DK133131-03 |
| Project ID | NIH-10850984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with myelodysplastic syndromes or those at risk of developing acute myeloid leukemia.
✕Less likely to help
Patients with other types of blood disorders unrelated to myelodysplastic syndromes may not benefit from this research.
What this research studies
This research investigates the role of endothelial cells, which are part of blood vessels, in the development and progression of myelodysplastic syndromes (MDS). It aims to understand how these cells influence hematopoietic stem cells and contribute to the disease, particularly in older adults. By examining the interactions between these cells and the bone marrow environment, the study seeks to identify potential therapeutic targets. The research will involve analyzing bone marrow samples and assessing the molecular changes that occur during disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with myelodysplastic syndromes and related acute myeloid leukemias.
How similar studies have gone: Previous research has shown that targeting the endothelial niche can be beneficial in other hematological conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Bajaj, Jeevisha — University of Rochester
- Study coordinator: Bajaj, Jeevisha
Related research
Other NIH-funded projects on the same topics.
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Interferon-γ plus donor immune cells to fight AML/MDS after partial donor transplant
This project tests a therapy that adds a signaling protein, IFN-γ, with donor immune cells to help treat relapsed AML/MDS after a haploidentical stem cell transplant.
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Whole-genome sequencing to refine risk in myelodysplastic syndromes (MDS) for older adults
This project uses clinical whole-genome sequencing to improve genetic profiling and better predict how MDS will progress in older patients.
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Targeting gasdermin D to treat myelodysplastic syndromes in people with bone marrow inflammation
A research project aims to find new ways to treat myelodysplastic syndromes by blocking a protein (gasdermin D) involved in harmful bone marrow inflammation.
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Understanding why some MDS patients relapse after a stem cell transplant
A study of patients with myelodysplastic syndromes after stem cell transplant to learn the cellular changes and gene activity that lead to relapse, with the goal of guiding future treatments.
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Risk factors and inflammation biomarkers for cardiovascular disease in older adults with myelodysplastic syndromes
A study focuses on older adults with myelodysplastic syndromes to understand why they have higher cardiovascular risk and how inflammatory proteins in the blood might help predict it.
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Therapeutic targeting of transcription-epigenetic defects in SF3B1-mutant MDS
A training-focused grant to help a clinician-scientist develop therapies for adults with a common bone marrow failure condition called SF3B1-mutant myelodysplastic syndrome (MDS).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.