Understanding how blood vessel cells affect myelodysplastic syndromes
Defining and Manipulating the Endothelial Niche in Myelodysplastic Syndromes
This study is looking at how certain cells in your blood vessels affect the way blood-forming cells work in people with myelodysplastic syndromes, especially in older adults, to find new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10850984 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial cells, which are part of blood vessels, in the development and progression of myelodysplastic syndromes (MDS). It aims to understand how these cells influence hematopoietic stem cells and contribute to the disease, particularly in older adults. By examining the interactions between these cells and the bone marrow environment, the study seeks to identify potential therapeutic targets. The research will involve analyzing bone marrow samples and assessing the molecular changes that occur during disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with myelodysplastic syndromes or those at risk of developing acute myeloid leukemia.
Not a fit: Patients with other types of blood disorders unrelated to myelodysplastic syndromes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with myelodysplastic syndromes and related acute myeloid leukemias.
How similar studies have performed: Previous research has shown that targeting the endothelial niche can be beneficial in other hematological conditions, suggesting potential for success in this area as well.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Bajaj, Jeevisha — University of Rochester
- Study coordinator: Bajaj, Jeevisha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.