Understanding how blood type affects bleeding and clotting risks
Defining the Role of Platelet ABO(H) Blood Group Antigens in Hemostasis and Thrombosis
This study is looking at how different blood types, especially type O, affect bleeding and clotting in people, to help us understand why some folks bleed more easily while others might have a higher chance of forming blood clots.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062030 on NIH RePORTER |
What this research studies
This research investigates the relationship between ABO blood group antigens and their impact on bleeding and clotting in patients. It aims to understand why individuals with type O blood are more prone to bleeding, while those with non-O blood types are at a higher risk for thrombosis. The study will utilize advanced techniques such as enzyme-linked immunosorbent assays (ELISA) and surface plasmon resonance to analyze how these blood group antigens influence platelet function and binding to critical proteins involved in blood clotting. By defining these mechanisms, the research seeks to provide insights that could lead to improved patient care and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with different ABO blood types, particularly those with type O and non-O blood types, who may be at risk for bleeding or clotting disorders.
Not a fit: Patients with blood disorders unrelated to ABO blood group antigens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and management strategies for patients at risk of bleeding or thrombosis based on their blood type.
How similar studies have performed: Previous research has indicated that blood type can influence bleeding and clotting risks, suggesting that this investigation builds on established findings in the field.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hollenhorst, Marie — Brigham and Women's Hospital
- Study coordinator: Hollenhorst, Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.