Understanding how blood transfusions can lead to immune reactions in patients.
Official title: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion. Project 3
Funded at University of Virginia · NIH-11070286 · Data updated 2026-11-12
This study is looking at how your immune system reacts when you get a blood transfusion, especially why some people develop antibodies against the donor blood, and it aims to find ways to prevent any bad reactions during transfusions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $369,345 |
| NIH project number | 5P01HL169552-02 |
| Project ID | NIH-11070286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who require blood transfusions, especially those with conditions like hemolytic anemia that may increase their risk of developing alloantibodies.
✕Less likely to help
Patients who do not require blood transfusions or who have no history of immune reactions to transfusions may not benefit from this research.
What this research studies
This research investigates the immune responses that occur when patients receive red blood cell (RBC) transfusions, particularly focusing on the development of alloantibodies against donor blood group antigens. By identifying risk factors associated with both the donor RBC units and the recipients' immune systems, the study aims to uncover strategies to prevent adverse reactions. The researchers will utilize murine models to explore how reticulocytes, a type of immature red blood cell, may influence the rates of alloimmunization. This work seeks to address a significant clinical need for effective interventions in transfusion medicine.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and outcomes for patients receiving blood transfusions by reducing the risk of immune reactions.
How similar studies have gone: Previous research has shown that understanding immune responses to blood transfusions can lead to better management strategies, indicating that this approach has potential for success.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Hudson, Krystalyn E — University of Virginia
- Study coordinator: Hudson, Krystalyn E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.