Understanding how blood stem cells stay inactive and what keeps them healthy
Towards Understanding Molecular Mechanisms of Human Hematopoietic Stem Cells' Quiescence
This study is looking at how certain cells in your blood, called hematopoietic stem cells, stay healthy and ready to make new blood cells, and it aims to find ways to improve their function, which could help in treating blood-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10806990 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that keep hematopoietic stem cells (HSCs) in a quiescent state, which is crucial for their longevity and ability to replenish blood. By focusing on lysosomal activity and its role in maintaining HSC quiescence, the study aims to identify ways to enhance the health and functionality of these stem cells. The researchers will use innovative techniques to analyze the mitochondrial membrane potential of HSCs and explore how modulating lysosomal function can impact their activity. This work is essential for developing better therapies that utilize HSCs for treating blood-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or cancers that may benefit from enhanced hematopoietic stem cell therapies.
Not a fit: Patients with non-hematological conditions or those who do not require stem cell interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for blood cancers and other conditions requiring stem cell treatments.
How similar studies have performed: Previous research has shown promising results in understanding stem cell quiescence and its implications for therapy, suggesting that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ghaffari, Saghi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ghaffari, Saghi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.