Understanding how blood stem cells recover after a transplant
Regulatory mechanisms of hematopoietic stem cell functions post-transplant
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11122344
This project aims to discover why blood-forming stem cells become less effective after a bone marrow transplant, hoping to improve patient outcomes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11122344 on ClinicalTrials.gov |
What this research studies
After a bone marrow transplant, the blood-forming stem cells that create all your blood and immune cells can get damaged and not work as well. This project wants to find out why these important stem cells lose their ability to regenerate and function properly over time. Researchers have found that tiny powerhouses within these cells, called mitochondria, change permanently and become less efficient after a transplant. By understanding these changes, especially how cells manage and clean up damaged mitochondria, we hope to find ways to help stem cells stay healthy and strong. This knowledge could lead to better ways to support patients recovering from bone marrow transplants.
Who could benefit from this research
Good fit: This foundational research is relevant to patients who have undergone or will undergo bone marrow transplantation for blood diseases.
Not a fit: Patients not undergoing bone marrow transplantation or those with conditions unrelated to blood stem cell function may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to help blood stem cells recover better after bone marrow transplantation, improving long-term health for patients.
How similar studies have performed: While the specific mechanisms of mitochondrial decline in HSCs post-transplant are still being uncovered, research into stem cell biology and mitochondrial health has shown promise in other areas.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FILIPPI, MARIE-DOMINIQUE — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: FILIPPI, MARIE-DOMINIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases