Understanding How Blood Stem Cells Form
Developing Next Generation Genetics for Understanding Hematopoietic Stem Cell Biology
This project aims to understand how the body creates its supply of blood stem cells, which are vital for healthy blood and treatments like bone marrow transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11141102 on NIH RePORTER |
What this research studies
Our bodies constantly need new blood cells, and these come from special cells called hematopoietic stem cells (HSCs) found in bone marrow. This project is creating new genetic tools to help scientists see exactly how these important HSCs are formed and maintained throughout life. By using these advanced tools in laboratory models, we hope to uncover the precise steps involved in building the adult blood stem cell supply. This deeper understanding is crucial because HSCs are the foundation for all blood cell types and are used in life-saving bone marrow transplant procedures.
Who could benefit from this research
Good fit: Patients with blood disorders or those who may need bone marrow transplants could eventually benefit from the foundational knowledge gained from this research.
Not a fit: Patients whose conditions are unrelated to blood stem cell function or blood cell production may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a much better understanding of blood stem cell biology, potentially improving treatments for blood disorders and bone marrow transplantation in the future.
How similar studies have performed: While existing genetic tools have been useful, this project focuses on developing novel, more precise tools to address previously unanswerable questions about blood stem cell formation.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Yazawa, Masayuki — Icahn School of Medicine at Mount Sinai
- Study coordinator: Yazawa, Masayuki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.