Understanding how blood stem cells divide and develop into different blood cells
Mechanisms of Asymmetric Cell Division in Developmental Hematopoiesis
This study is looking at how blood stem cells split and turn into different types of blood cells, which is important for keeping our blood healthy, and it uses fruit flies to help us learn more about how this process works in people and what happens when it goes wrong.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11013873 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how hematopoietic stem cells (HSCs) divide and differentiate into various blood cell types. It focuses on asymmetric cell division (ACD), which is crucial for producing a balanced and functional blood system. The study employs advanced techniques such as RNA interference and immunofluorescence to identify the molecular factors involved in ACD and examines how disruptions in this process can lead to blood disorders. By using a Drosophila model, the research aims to provide insights that could enhance our understanding of blood cell development in mammals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or conditions related to blood cell production.
Not a fit: Patients with non-hematological conditions or those not affected by blood cell production issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating blood disorders by improving our understanding of blood cell formation.
How similar studies have performed: Previous research has shown promising results in understanding cell division mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Goins, Lauren Monica — Stanford University
- Study coordinator: Goins, Lauren Monica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.