Understanding how blood stem cells develop from specific embryonic cells
Official title: Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endothelium
Funded at Fred Hutchinson Cancer Center · NIH-11052506 · Data updated 2026-11-12
This study is exploring how to create important blood and immune cells from early-stage cells in the body, which could help develop better treatments for blood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $440,000 |
| NIH project number | 5R01HL168110-03 |
| Project ID | NIH-11052506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those requiring blood stem cell transplantation.
✕Less likely to help
Patients with non-blood-related conditions or those who do not require stem cell therapies may not benefit from this research.
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are crucial for forming blood and immune cells, can be generated from embryonic precursors known as hemogenic endothelium. The project aims to identify the unique molecular factors that determine the fate of these stem cells during development. By using advanced techniques, including a specialized ex vivo vascular niche platform and single-cell analysis, the researchers hope to uncover the conditions necessary for producing functional HSCs in the lab. This could lead to improved methods for generating HSCs for therapeutic use in treating blood disorders.
Why it matters
Potential benefit: If successful, this research could provide a reliable method for generating hematopoietic stem cells, enhancing treatment options for patients with blood disorders.
How similar studies have gone: Previous research has shown promise in generating stem cells from pluripotent sources, but this approach aims to refine and enhance those methods, making it a novel exploration.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Hadland, Brandon K — Fred Hutchinson Cancer Center
- Study coordinator: Hadland, Brandon K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.