Understanding how blood stem cells develop from embryonic cells
Cellular barcoding of developmental hematopoiesis
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11037986
This study is looking into where blood-making stem cells come from in embryos to help us understand how they grow and work, which could eventually lead to better ways to create these cells in the lab for treating blood disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11037986 on ClinicalTrials.gov |
What this research studies
This research investigates the origins of hematopoietic stem cells (HSCs), which are crucial for producing all types of blood cells. By utilizing advanced barcoding technology, the study aims to trace the lineage of these stem cells from their embryonic sources, enhancing our understanding of their development and function. The goal is to identify the specific embryonic sites that generate long-term HSCs and the factors influencing their behavior. This knowledge could lead to improved methods for generating HSCs in the lab, which is essential for treating various blood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or those who may benefit from blood stem cell therapies.
Not a fit: Patients with non-blood-related conditions or those over 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for blood diseases by enabling the efficient generation of functional blood stem cells.
How similar studies have performed: Other research has shown promise in using barcoding technology for tracing cell lineages, indicating potential success for this approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOWLING, SARAH — STANFORD UNIVERSITY
- Study coordinator: BOWLING, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.