Understanding how blood stem cells develop from embryonic cells
Official title: Cellular barcoding of developmental hematopoiesis
Funded at Stanford University · NIH-11037986 · Data updated 2026-11-12
This study is looking into where blood-making stem cells come from in embryos to help us understand how they grow and work, which could eventually lead to better ways to create these cells in the lab for treating blood disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | February 16, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL164969-04 |
| Project ID | NIH-11037986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those who may benefit from blood stem cell therapies.
✕Less likely to help
Patients with non-blood-related conditions or those over 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates the origins of hematopoietic stem cells (HSCs), which are crucial for producing all types of blood cells. By utilizing advanced barcoding technology, the study aims to trace the lineage of these stem cells from their embryonic sources, enhancing our understanding of their development and function. The goal is to identify the specific embryonic sites that generate long-term HSCs and the factors influencing their behavior. This knowledge could lead to improved methods for generating HSCs in the lab, which is essential for treating various blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for blood diseases by enabling the efficient generation of functional blood stem cells.
How similar studies have gone: Other research has shown promise in using barcoding technology for tracing cell lineages, indicating potential success for this approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Bowling, Sarah — Stanford University
- Study coordinator: Bowling, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.