Understanding how blood stem cells communicate with their environment throughout the day
Official title: Investigating the Heterogeneous Intercellular Signaling of Hematopoietic Stem and Progenitor Cells and its Changes around the Circadian Clock
Funded at University of Southern California · NIH-11071616 · Data updated 2026-11-12
This study looks at how important blood-making cells in your bone marrow talk to other cells around them throughout the day, which could help us understand how to better treat blood disorders and improve healing after things like bleeding or infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL178286-01 |
| Project ID | NIH-11071616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders or those undergoing treatments that affect blood cell production.
✕Less likely to help
Patients with stable blood conditions or those not affected by blood cell production issues may not benefit from this research.
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are crucial for blood and immune system health, communicate with surrounding cells in the bone marrow. It focuses on the signaling pathways that regulate these interactions and how they change over the course of a day, or circadian rhythm. By examining the complex communication networks between HSCs and their niche, the study aims to uncover the mechanisms that allow blood regeneration to adapt to various challenges like bleeding and infection. This could lead to new insights into blood disorders and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders by enhancing our understanding of blood regeneration processes.
How similar studies have gone: Previous research has shown promising results in understanding cell signaling in blood regeneration, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Thomas, Zachary Vander — University of Southern California
- Study coordinator: Thomas, Zachary Vander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.