Understanding how blood stem cells communicate with their environment throughout the day
Investigating the Heterogeneous Intercellular Signaling of Hematopoietic Stem and Progenitor Cells and its Changes around the Circadian Clock
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11071616
This study looks at how important blood-making cells in your bone marrow talk to other cells around them throughout the day, which could help us understand how to better treat blood disorders and improve healing after things like bleeding or infections.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11071616 on ClinicalTrials.gov |
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are crucial for blood and immune system health, communicate with surrounding cells in the bone marrow. It focuses on the signaling pathways that regulate these interactions and how they change over the course of a day, or circadian rhythm. By examining the complex communication networks between HSCs and their niche, the study aims to uncover the mechanisms that allow blood regeneration to adapt to various challenges like bleeding and infection. This could lead to new insights into blood disorders and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with blood disorders or those undergoing treatments that affect blood cell production.
Not a fit: Patients with stable blood conditions or those not affected by blood cell production issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders by enhancing our understanding of blood regeneration processes.
How similar studies have performed: Previous research has shown promising results in understanding cell signaling in blood regeneration, indicating that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, ZACHARY VANDER — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: THOMAS, ZACHARY VANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases