Understanding how blood stem cells are influenced by their surroundings
Reprogramming of hematopoietic stem cells during contact with the perivascular niche
This research explores how blood stem cells interact with their surrounding cells to improve treatments for blood diseases and cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11100003 on NIH RePORTER |
What this research studies
We want to understand how blood stem cells, which are crucial for treating many blood diseases and cancers, interact with the special cells around them. These interactions are important because they help regulate how stem cells work and mature as they move through the body during development. By studying these processes in model systems like zebrafish and mice, we hope to discover new ways to make stem cell transplants more effective. Our goal is to uncover fundamental principles of stem cell behavior that could lead to better patient outcomes.
Who could benefit from this research
Good fit: Patients with blood diseases and cancers who may need or have undergone hematopoietic stem cell transplantation could potentially benefit from future advancements stemming from this basic research.
Not a fit: Patients who do not have blood diseases or cancers, or those not undergoing stem cell transplantation, would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for hematopoietic stem cell transplantation, resulting in better patient outcomes and survival for those with blood diseases and cancers.
How similar studies have performed: This research addresses fundamental questions about cellular interactions, building upon existing knowledge but exploring novel aspects of HSPC regulation and niche contact.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Tamplin, Owen James — University of Wisconsin-Madison
- Study coordinator: Tamplin, Owen James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.