Understanding how blood stem cell environments change in blood disorders
Official title: Clonal dynamics of the blood stem cell niche
Funded at Boston Children's Hospital · NIH-10781972 · Data updated 2026-11-12
This study is looking at how myelodysplastic syndrome (MDS) changes the environment where blood stem cells grow, using zebrafish to see how these changes happen and what they mean for the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $90,000 |
| NIH project number | 5K99DK134760-02 |
| Project ID | NIH-10781972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with myelodysplastic syndrome or related blood disorders.
✕Less likely to help
Patients with non-hematological conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how clonal hematological disorders, particularly myelodysplastic syndrome (MDS), affect the environment where blood stem cells develop. Using a novel zebrafish model, researchers will explore the behavior of blood cell niches and how they respond to MDS. The study employs advanced genetic techniques, including CRISPR-CAS9, to trace and analyze the changes in specific cell types within the niche. By examining these interactions, the research aims to uncover the underlying mechanisms that contribute to disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of blood disorders, potentially improving outcomes for patients with MDS.
How similar studies have gone: While the specific approach using zebrafish and CRISPR in this context is novel, similar studies have shown promise in understanding blood disorders through genetic modeling.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Baron, Chloe Sophie — Boston Children's Hospital
- Study coordinator: Baron, Chloe Sophie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.