Understanding how blood production adapts during emergencies
Official title: Emergency Myelopoiesis in the Control of Blood Production
Funded at Columbia University Health Sciences · NIH-11042708 · Data updated 2026-11-12
This study is looking at how your body makes blood cells when it needs them most, like during inflammation or cancer, and it’s for anyone interested in understanding how these processes work and what they mean for health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,008,571 |
| NIH project number | 5R35HL171521-02 |
| Project ID | NIH-11042708 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders, chronic inflammation, or cancers that affect blood cell production.
✕Less likely to help
Patients with stable blood conditions or those not experiencing any blood-related issues may not benefit from this research.
What this research studies
This research investigates how the body produces blood cells in response to various demands, particularly during emergencies like inflammation or cancer. It focuses on the role of hematopoietic stem cells and progenitor cells in the bone marrow, examining how they respond to signals from their environment to increase blood cell production. The study aims to uncover the mechanisms behind emergency myelopoiesis, which can lead to overproduction of certain blood cells in chronic conditions. By developing a novel platform to model these interactions, the research seeks to enhance our understanding of blood cell formation and its implications for health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders and cancers by optimizing blood cell production.
How similar studies have gone: Previous research has shown promise in understanding blood cell production mechanisms, making this approach a continuation of established findings rather than entirely novel.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Passegue, Emmanuelle — Columbia University Health Sciences
- Study coordinator: Passegue, Emmanuelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.