Understanding how blood pressure and heart rate respond to stress and their impact on aging and Alzheimer's disease
Epidemiology of blood pressure responses to perturbations: Correlates and prognosis for vascular risk, end-organ damage, cognitive aging and preclinical Alzheimer's disease
This study is looking at how your blood pressure and heart rate change when you're stressed or active, to see if these changes can help us understand your heart and brain health better, especially as you age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11056030 on NIH RePORTER |
What this research studies
This research investigates how blood pressure (BP) and heart rate (HR) respond to various stressors and how these responses may indicate resilience in the cardiovascular system. By analyzing the fluctuations in BP and HR after stimuli such as mental tasks and exercise, the study aims to develop new indicators that could predict risks for conditions like hypertension, cognitive decline, and Alzheimer's disease. Patients will be monitored for their BP and HR responses, providing valuable data on how these metrics relate to overall health and aging. The goal is to better understand the relationship between cardiovascular responses and brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who may be experiencing cognitive changes or have risk factors for cardiovascular disease.
Not a fit: Patients who are under 21 years old or do not have any cardiovascular or cognitive health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing cognitive decline and Alzheimer's disease in aging populations.
How similar studies have performed: Other research has shown promise in using cardiovascular response metrics to predict cognitive outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Ramachandran, Vasan S — University of Texas Hlth Science Center
- Study coordinator: Ramachandran, Vasan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.