Understanding how blood pressure affects fat cells around blood vessels
The perivascular adipocyte: integrating mechanical and structural cues into vasoactive function
['FUNDING_P01'] · MICHIGAN STATE UNIVERSITY · NIH-10980463
This study is looking at how a special type of fat around your blood vessels affects blood pressure and how high blood pressure changes how these fat cells work, which could help us understand better ways to manage hypertension.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10980463 on ClinicalTrials.gov |
What this research studies
This research investigates the role of perivascular adipose tissue (PVAT) in regulating blood pressure and how hypertension alters the function of fat cells and their progenitors in this tissue. The study aims to understand how mechanical forces from blood pressure impact the ability of these fat cells to develop and function properly. By examining the interaction between these forces and the surrounding extracellular matrix, the research seeks to uncover the mechanisms behind PVAT dysfunction in the context of hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing hypertension or related cardiovascular issues.
Not a fit: Patients who do not have hypertension or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing hypertension and improving cardiovascular health by targeting the function of perivascular fat cells.
How similar studies have performed: While the specific focus on perivascular adipose tissue in the context of hypertension is relatively novel, related studies have shown promising results in understanding the role of adipose tissue in cardiovascular health.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONTRERAS, GENARO ANDRES — MICHIGAN STATE UNIVERSITY
- Study coordinator: CONTRERAS, GENARO ANDRES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.