Understanding how blood group antigens affect immune responses and transfusion safety
Leveraging New Approaches to Unravel ABO Blood Group Immunity and Incompatibility
['FUNDING_P01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10782161
This study is looking at how our immune system reacts to different blood types to help prevent problems that can happen when someone receives the wrong blood during a transfusion, making blood donations and transfusions safer for everyone.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10782161 on ClinicalTrials.gov |
What this research studies
This research investigates the ABO blood group system, focusing on how the body's immune system responds to different blood group antigens and the formation of antibodies against them. By utilizing advanced tools and methodologies, the research aims to uncover the factors that lead to hemolytic transfusion reactions, which can occur when incompatible blood is transfused. The study seeks to improve our understanding of these immune responses, potentially leading to better blood transfusion practices and patient safety.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced transfusion reactions or those requiring blood transfusions, particularly those with rare blood types.
Not a fit: Patients who have never required a blood transfusion or have no history of blood group incompatibility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the safety of blood transfusions and organ transplants by reducing the risk of adverse immune reactions.
How similar studies have performed: Previous research in the field of glycosciences has shown promise in understanding blood group antigens, but this specific approach to ABO blood group immunity is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STOWELL, SEAN R — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: STOWELL, SEAN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.