Understanding how blood flow varies in the heart and its impact on treatment for heart disease
Official title: Mechanisms of coronary flow heterogeneity: Implications for coronary sinus occlusion therapy
Funded at California Medical Innovations Institute · NIH-10885952 · Data updated 2026-11-12
This study is looking at how blood flows in the hearts of people with coronary heart disease to better understand how different treatments can help improve blood and oxygen delivery to the heart muscle.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Medical Innovations Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $667,433 |
| NIH project number | 5R01HL160997-03 |
| Project ID | NIH-10885952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with coronary heart disease who experience issues related to blood flow and ischemia.
✕Less likely to help
Patients without coronary heart disease or those with stable heart conditions may not benefit from this research.
What this research studies
This research investigates the differences in blood flow within the heart, particularly in patients with coronary heart disease (CHD). By using advanced computer models that accurately represent the heart's anatomy, the study aims to uncover the biological and physical factors that contribute to this variability in blood flow. The goal is to develop a comprehensive model that explains how certain treatments, like coronary sinus occlusion, can affect blood flow and oxygen delivery to the heart muscle. This research could lead to improved treatment strategies for patients suffering from ischemia due to CHD.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with coronary heart disease, potentially improving their heart function and quality of life.
How similar studies have gone: Previous research has shown promise in using advanced modeling techniques to understand coronary blood flow, suggesting that this approach could yield valuable insights.
Where this research is happening
-
California Medical Innovations Institute
San Diego, United States Active
Researchers
- Principal investigator: Kassab, Ghassan S — California Medical Innovations Institute
- Study coordinator: Kassab, Ghassan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.