Understanding how blood flow changes lead to brain aneurysms
Hemodynamically induced molecules regulating the initiation of intracranial aneurysms
This study is looking at how changes in blood flow can lead to the formation of dangerous brain aneurysms, using rabbits to understand which genes are involved, with the hope of finding new ways to prevent these conditions and keep your arteries healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10592695 on NIH RePORTER |
What this research studies
This research investigates the molecular signals that trigger the formation of intracranial aneurysms (IAs), which can lead to severe strokes. By examining gene expression in arteries during the development of IAs, the study aims to uncover how changes in blood flow can weaken arterial walls. The researchers will use a rabbit model to analyze how specific genes are activated in response to altered blood flow, potentially identifying new targets for preventing aneurysm formation. This approach could provide insights into the biological processes that contribute to IAs and help develop preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with risk factors for intracranial aneurysms, such as a family history of aneurysms or certain vascular conditions.
Not a fit: Patients who have already experienced a ruptured aneurysm or those without risk factors for aneurysm formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing the formation of intracranial aneurysms, significantly reducing the risk of stroke for at-risk patients.
How similar studies have performed: While the specific approach of examining gene expression in response to hemodynamic changes is innovative, similar studies have shown promise in understanding vascular conditions, suggesting potential for success.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Kolega, John P — State University of New York at Buffalo
- Study coordinator: Kolega, John P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.