Understanding how blood flow affects the development of coronary arteries
Effect of shear stress on coronary smooth muscle maturation
This study is looking at how blood flow affects the growth of coronary arteries in chick embryos, specifically how it influences the movement and development of certain cells, and it aims to help us understand how blood flow helps shape healthy arteries.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Portland NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10580556 on NIH RePORTER |
What this research studies
This research investigates how the flow of blood, which creates shear stress, influences the development of coronary arteries. It focuses on the early stages of coronary artery formation in chick embryos, examining how shear stress affects smooth muscle cells' migration and maturation. The study will utilize in ovo injections to manipulate specific enzymes involved in this process, allowing researchers to observe changes in smooth muscle behavior in response to varying levels of shear stress. By understanding these mechanisms, the research aims to uncover the regulatory roles of blood flow in coronary artery development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with congenital coronary artery anomalies or related cardiovascular conditions.
Not a fit: Patients with fully developed coronary arteries and no history of congenital heart defects may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of coronary artery formation, potentially informing treatments for coronary artery anomalies.
How similar studies have performed: While the specific regulatory role of shear stress in coronary artery development is not well-studied, related research has shown that fluid dynamics significantly influence vascular development in other contexts.
Where this research is happening
Portland, United States
- University of Portland — Portland, United States (Active)
Researchers
- Principal investigator: Dyer, Laura Ann — University of Portland
- Study coordinator: Dyer, Laura Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.