Understanding how blood flow affects stem cell development
Biomechanical Determinants of Hematopoietic Stem Cell Potential
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10982451
This study is looking at how blood flow affects the growth of blood-making stem cells, with the goal of finding better ways to create these cells for transplants, which could help improve treatments for blood diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10982451 on ClinicalTrials.gov |
What this research studies
This research investigates the role of biomechanical forces, particularly blood flow, in the development of hematopoietic stem cells (HSCs). By examining how these forces influence energy metabolism and mitochondrial function in stem cell precursors, the study aims to improve methods for generating HSCs that can be used in transplants. The researchers will explore how to harness these biophysical cues to create customized stem cells for therapeutic purposes, potentially enhancing treatment options for blood diseases. Patients may benefit from advancements in stem cell transplantation and improved outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring hematopoietic stem cell transplants, particularly those with blood disorders.
Not a fit: Patients who do not require stem cell transplants or have conditions unrelated to hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better sources of hematopoietic stem cells for transplants, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using biomechanical approaches to enhance stem cell development, indicating potential for success in this area.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WENZEL, PAMELA LYNN — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: WENZEL, PAMELA LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.