Understanding how blood flow affects heart valve disease
Official title: Hemodynamics and KLF2/4 regulate myxomatous valve pathogenesis
Funded at University of Pennsylvania · NIH-11113788 · Data updated 2026-11-12
This study is looking at how blood flow and certain proteins affect heart valves in people with myxomatous valve disease, hoping to find new ways to understand and treat this common heart condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HL173955-02 |
| Project ID | NIH-11113788 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with myxomatous valve disease, particularly those who may not have a genetic basis for their condition.
✕Less likely to help
Patients with myxomatous valve disease caused by known genetic syndromes may not benefit from this research.
What this research studies
This research investigates myxomatous valve disease (MVD), a common heart valve condition that can lead to serious health issues. The study focuses on how blood flow and specific proteins (KLF2 and KLF4) influence the health of heart valves. By examining the effects of hemodynamic forces on valve cells, the researchers aim to uncover new insights into the disease's development and progression. The approach includes both laboratory experiments and analysis of genetic factors related to valve health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive strategies for patients with myxomatous valve disease.
How similar studies have gone: Previous research has shown promising results in understanding valve disease through similar approaches, indicating potential for success in this study.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Pace, Jesse — University of Pennsylvania
- Study coordinator: Pace, Jesse
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.