Understanding how blood flow affects brain aneurysms
Bridging the Gap from Hemodynamic Stress to Intracranial Aneurysm Instability: An Integrated Multimodal Approach
This study is looking at how unusual blood flow can weaken the walls of brain aneurysms, with the goal of creating tools to help predict and prevent them from bursting, so it’s especially for people who have or are at risk for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11078673 on NIH RePORTER |
What this research studies
This research aims to develop tools to predict and prevent the rupture of intracranial aneurysms (IAs) by studying how abnormal blood flow affects the walls of these aneurysms. The team will use advanced imaging techniques and dynamic modeling to analyze human samples and understand the biological mechanisms at play. By integrating data from various sources, they hope to identify specific signaling pathways that contribute to aneurysm instability. This innovative approach combines multiple disciplines to address critical questions about aneurysm behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with intracranial aneurysms who are at risk of rupture.
Not a fit: Patients with stable intracranial aneurysms that are not at risk of rupture may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention strategies for aneurysm ruptures, potentially saving lives.
How similar studies have performed: Previous research has shown promise in using advanced imaging and modeling techniques to study aneurysms, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kaneko, Naoki — University of California Los Angeles
- Study coordinator: Kaneko, Naoki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.