Understanding how blood flow affects brain aneurysms
Official title: Bridging the Gap from Hemodynamic Stress to Intracranial Aneurysm Instability: An Integrated Multimodal Approach
Funded at University of California Los Angeles · NIH-11078673 · Data updated 2026-11-12
This study is looking at how unusual blood flow can weaken the walls of brain aneurysms, with the goal of creating tools to help predict and prevent them from bursting, so it’s especially for people who have or are at risk for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $484,491 |
| NIH project number | 5R01NS121286-05 |
| Project ID | NIH-11078673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with intracranial aneurysms who are at risk of rupture.
✕Less likely to help
Patients with stable intracranial aneurysms that are not at risk of rupture may not benefit from this research.
What this research studies
This research aims to develop tools to predict and prevent the rupture of intracranial aneurysms (IAs) by studying how abnormal blood flow affects the walls of these aneurysms. The team will use advanced imaging techniques and dynamic modeling to analyze human samples and understand the biological mechanisms at play. By integrating data from various sources, they hope to identify specific signaling pathways that contribute to aneurysm instability. This innovative approach combines multiple disciplines to address critical questions about aneurysm behavior.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention strategies for aneurysm ruptures, potentially saving lives.
How similar studies have gone: Previous research has shown promise in using advanced imaging and modeling techniques to study aneurysms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kaneko, Naoki — University of California Los Angeles
- Study coordinator: Kaneko, Naoki
Related research
Other NIH-funded projects on the same topics.
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Understanding how brain aneurysm walls and shape change over time
This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.
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Predicting brain aneurysm growth with advanced 4D MRI and tensor math
A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.
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How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
-
Reprogramming blood-vessel lining cells in inherited brain aneurysms
This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.
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How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms
Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.
-
How cells' cleanup of vessel attachments may affect brain aneurysms
This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.