Understanding how blood flow affects a specific bleeding disorder.
Official title: Multimeric Structural Degradation of vWF in Turbulent Flows
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10991809 · Data updated 2026-11-12
This study is looking at how a bleeding disorder called Acquired von Willebrand Syndrome happens in people with severe heart valve problems or those using certain heart devices, to better understand how changes in blood flow can affect their condition and help improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | January 5, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $578,994 |
| NIH project number | 5R01HL166334-03 |
| Project ID | NIH-10991809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with Acquired von Willebrand Syndrome, particularly those with severe aortic stenosis or those using continuous-flow left ventricular assist devices.
✕Less likely to help
Patients with other types of bleeding disorders not related to abnormal blood flow may not benefit from this research.
What this research studies
This research investigates Acquired von Willebrand Syndrome (AvWS), a bleeding disorder linked to abnormal blood flow conditions, particularly in patients with severe aortic stenosis or those using continuous-flow left ventricular assist devices. The study aims to characterize how high molecular weight multimers of von Willebrand factor degrade under different blood flow conditions, focusing on the mechanical and enzymatic processes involved. By examining these degradation mechanisms, the research seeks to provide insights into the timing and conditions that lead to this bleeding disorder, which could improve patient management and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of bleeding disorders associated with abnormal blood flow, potentially improving patient outcomes.
How similar studies have gone: While the mechanisms of von Willebrand factor degradation have been studied, this research aims to explore a novel approach by focusing on the specific conditions of turbulent blood flow, making it a unique investigation.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Jhun, Choon-Sik — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Jhun, Choon-Sik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.