Understanding how blood coagulation proteins interact and function
Macromolecular Recognition in Coagulation
['FUNDING_P01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10768829
This study is looking at how certain proteins in your blood work together to help with clotting, which is important for healing, and it aims to find out how changes in one part of these proteins can affect their overall function, which could help us understand blood clotting better and find new ways to treat related conditions.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10768829 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms of blood coagulation by studying the prothrombinase complex, which includes prothrombin and thrombin. It aims to uncover how binding at one site on these proteins can influence their function at other sites, a phenomenon known as allostery. By combining biophysical studies with structural and functional measurements, the research seeks to provide new insights into the behavior of coagulation factors and their interactions. This could lead to a better understanding of blood clotting processes and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with bleeding disorders such as hemophilia or other coagulation factor deficiencies.
Not a fit: Patients with coagulation disorders that are not related to the factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood coagulation disorders, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding coagulation mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRISHNASWAMY, SRIRAM — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: KRISHNASWAMY, SRIRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.