Understanding how blood coagulation factors interact
Structural enzymology of factor V activation
This study is looking at how certain proteins in your blood, called factor V, thrombin, and meizothrombin, work together to help your blood clot properly, using special imaging technology to see them in detail, which could help us understand and improve treatments for blood clotting issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11075822 on NIH RePORTER |
What this research studies
This research investigates the structural details of how blood coagulation factors, specifically factor V and its interactions with thrombin and meizothrombin, function in the blood clotting process. Using advanced cryo-electron microscopy (cryo-EM), the team aims to visualize these proteins at a high resolution to better understand their roles in initiating blood coagulation. By revealing the molecular architecture of these interactions, the research seeks to provide insights into the mechanisms that regulate blood clotting, which is crucial for maintaining hemostasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bleeding disorders or conditions that affect blood coagulation.
Not a fit: Patients with unrelated health issues or those not affected by blood coagulation disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood coagulation disorders, enhancing patient outcomes in conditions related to abnormal clotting.
How similar studies have performed: Previous research using cryo-EM has successfully elucidated protein structures, suggesting that this approach may yield valuable insights into blood coagulation mechanisms.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Di Cera, Enrico — Saint Louis University
- Study coordinator: Di Cera, Enrico
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.