Understanding How Blood Clotting Proteins Protect Our Cells
Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases
This research explores how specific proteins involved in blood clotting also help protect the cells lining our blood vessels and regulate cell growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11124708 on NIH RePORTER |
What this research studies
Our bodies have a protein called thrombomodulin (TM) on the surface of blood vessel cells, which acts like a switch for another protein called thrombin, changing it from a clot-forming agent to one that activates protective processes. This activated protein then helps shield cells and reduce inflammation. We are learning how TM connects to the cell's internal framework and influences signals that control cell growth and survival. This work aims to uncover the detailed ways TM interacts with other cell signals to keep blood vessels healthy and prevent uncontrolled cell changes.
Who could benefit from this research
Good fit: Patients with conditions related to blood clotting disorders, inflammation, or certain types of cell growth abnormalities might eventually benefit from this foundational knowledge.
Not a fit: Patients whose conditions are unrelated to blood clotting, inflammation, or the specific cellular pathways being studied may not directly benefit from this particular basic research.
Why it matters
Potential benefit: Understanding these fundamental processes could lead to new strategies for treating conditions involving abnormal blood clotting, inflammation, and diseases characterized by uncontrolled cell proliferation.
How similar studies have performed: This research builds upon recent findings and preliminary data, exploring novel aspects of known biological pathways related to blood clotting and cell protection.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Rezaie, Alireza R. — Oklahoma Medical Research Foundation
- Study coordinator: Rezaie, Alireza R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.