Understanding how blood clotting affects liver healing after surgery
Novel coagulation-dependent mechanisms of liver regeneration to detect and prevent liver dysfunction after partial hepatectomy
This study is looking at how blood clotting affects the healing of the liver after surgery to remove part of it, and it hopes to find ways to predict problems and improve recovery for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10862608 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which blood coagulation influences liver regeneration following partial hepatectomy, a surgical procedure to remove part of the liver. It aims to identify biomarkers that can predict complications like post-hepatectomy liver failure and to explore new therapeutic targets that could enhance liver recovery. By analyzing liver and plasma samples from patients and using experimental models, the study seeks to understand how increased blood clotting may stimulate liver regeneration. This could lead to better management strategies for patients undergoing liver surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for partial hepatectomy due to liver disease or tumors.
Not a fit: Patients who have already experienced severe liver dysfunction or those not undergoing liver surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance liver regeneration and reduce the risk of liver failure after surgery.
How similar studies have performed: Previous research has shown promising results in understanding liver regeneration mechanisms, but this specific approach focusing on coagulation is relatively novel.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Luyendyk, James P — Michigan State University
- Study coordinator: Luyendyk, James P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.