Understanding how blood cells develop from their origins
Official title: High resolution lineage tracing of developmental hematopoiesis
Funded at Boston Children's Hospital · NIH-11032887 · Data updated 2026-11-12
This study is looking into how blood cells are made and where they come from, using special techniques to track them closely, which could help us find better ways to create blood cells for treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 5, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $668,787 |
| NIH project number | 5R01HL158192-03 |
| Project ID | NIH-11032887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those requiring blood cell therapies.
✕Less likely to help
Patients with non-blood-related conditions or those who do not require blood cell treatments may not benefit from this research.
What this research studies
This research investigates the origins of blood cells to improve our understanding of how these cells develop and function. By using advanced techniques like in situ mammalian barcoding, the researchers aim to trace the lineage of blood cells at a single-cell level. This approach will help identify the true sources of hematopoietic stem cells and progenitors, which are crucial for lifelong blood production. The findings could lead to better methods for producing blood cells and tissues for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders and enhance the production of blood cells for transplantation.
How similar studies have gone: Other research has shown promise using similar lineage tracing techniques, indicating potential for success in this area.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Camargo, Fernando — Boston Children's Hospital
- Study coordinator: Camargo, Fernando
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.