Understanding how blood cell development is influenced by the blood vessel environment.
Epigenetic control of vascular niche capacity to support hematopoiesis.
This study is looking at how the area around blood vessels in the bone marrow helps shape blood cell development, especially for people who have had chemotherapy or stem cell transplants, to find ways to boost the growth of important blood-making cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11042757 on NIH RePORTER |
What this research studies
This research investigates how the vascular niche, or the environment surrounding blood vessels in the bone marrow, affects the development of blood cells. It focuses on understanding the mechanisms that can enhance the diversity of hematopoietic stem cells (HSCs), which are crucial for producing various blood cells. By using advanced genetic screening techniques in zebrafish, the study aims to identify factors that can be manipulated to improve HSC function, especially in patients who have undergone chemotherapy or stem cell transplants. The research employs cutting-edge methods like single-cell RNA sequencing and ATAC sequencing to analyze the genetic and epigenetic changes in these environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients over 21 years old who have undergone chemotherapy or hematopoietic stem cell transplantation and are experiencing issues related to blood cell production.
Not a fit: Patients with blood disorders who have not received chemotherapy or stem cell transplants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with blood disorders by enhancing the effectiveness of hematopoietic stem cell therapies.
How similar studies have performed: Other research has shown promising results in manipulating the microenvironment to enhance blood cell development, indicating that this approach may be effective.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Blaser, Bradley Wayne — Ohio State University
- Study coordinator: Blaser, Bradley Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.