Understanding how blood cancers evolve at the cellular level
Official title: Dissecting Clonal Evolution of Myeloid Malignancies
Funded at Veterans Health Administration · NIH-11003768 · Data updated 2026-11-12
This study is looking at how certain blood cancers, like acute myeloid leukemia, change and grow by examining individual cells, especially in older veterans, to help us understand the disease better and improve treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX005991-02 |
| Project ID | NIH-11003768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myeloid malignancies, particularly those with acute myeloid leukemia or myelodysplastic syndromes.
✕Less likely to help
Patients with other types of cancers or those without myeloid malignancies may not benefit from this research.
What this research studies
This research investigates the clonal evolution of myeloid malignancies, particularly acute myeloid leukemia (AML), using advanced single-cell DNA sequencing techniques. By analyzing individual cells, the study aims to identify specific clonal populations and their mutations, which can provide insights into how these cancers develop and progress. The research focuses on the aging veteran population, where these blood cancers are increasingly prevalent, and seeks to connect genetic mutations to the behavior of cancer cells. This approach may lead to a better understanding of the disease and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more precise treatments for patients with myeloid malignancies by identifying specific mutations and clonal characteristics.
How similar studies have gone: Previous research has shown promise in using single-cell sequencing techniques to understand cancer evolution, indicating that this approach could yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Ferrell, Paul B — Veterans Health Administration
- Study coordinator: Ferrell, Paul B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.