Understanding how blood-brain barrier function is regulated after a stroke.
Endothelial Cell Epigenetics and Blood-Brain Barrier.
This study is looking at how certain genes in the brain's blood vessels change after a stroke, with the goal of finding new ways to help improve recovery for stroke patients by making the blood-brain barrier work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11042146 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic mechanisms in the development and maintenance of the blood-brain barrier (BBB), particularly after a stroke. The study aims to identify how certain genes are regulated in brain endothelial cells, which are crucial for BBB integrity. By exploring the functions of specific epigenetic enzymes, the researchers hope to uncover new therapeutic targets that could help restore BBB function and improve recovery outcomes for stroke patients. The research involves both laboratory experiments and analysis of gene expression patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a stroke and are over 21 years old.
Not a fit: Patients who have not had a stroke or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore blood-brain barrier function and improve recovery for stroke patients.
How similar studies have performed: Other research has shown promise in targeting vascular components for improving outcomes after stroke, suggesting that this approach could be beneficial.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Thankamani Pandit, Peeyush Kumar — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Thankamani Pandit, Peeyush Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.