Understanding how blood-brain barrier disruption affects cognitive decline after a stroke
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
This study is looking at how changes in the protective barrier around the brain after a stroke might help us predict if someone will have trouble with thinking and memory later on, using special brain scans to keep an eye on these changes in stroke patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11126639 on NIH RePORTER |
What this research studies
This research investigates the relationship between blood-brain barrier (BBB) disruption and cognitive decline following a stroke. It aims to determine if changes in the BBB, observable through MRI scans, can predict the risk of developing post-stroke cognitive impairment and dementia. The study will utilize advanced imaging techniques to monitor these changes over time in patients who have experienced a stroke, helping to identify those at higher risk for cognitive issues. By translating these findings into clinical practice, the research seeks to improve early detection and intervention strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a stroke and are at risk for cognitive decline.
Not a fit: Patients who have not had a stroke or those with pre-existing severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification and treatment of cognitive decline in stroke survivors, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of blood-brain barrier integrity in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Leigh, Richard — Johns Hopkins University
- Study coordinator: Leigh, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.