Understanding how blood-brain barrier changes affect cognitive recovery after surgery
Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorder:Cognitive Recovery after Elective Surgery
This study is looking at how problems with the blood-brain barrier might affect thinking and memory after surgery in older adults, using a special brain scan to help understand these changes and improve recovery after major surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10561705 on NIH RePORTER |
What this research studies
This research investigates the relationship between blood-brain barrier (BBB) dysfunction and cognitive issues that can arise after surgery, particularly in older adults. By using a specialized brain imaging technique called water exchange index MRI (WEI-MRI), the study aims to identify how changes in the BBB may predict the risk of postoperative delirium and cognitive dysfunction. The research involves a longitudinal approach, tracking older patients undergoing major elective surgeries to gather data on their cognitive recovery. The ultimate goal is to develop strategies that enhance cognitive safety during surgical procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65 years, who are scheduled for major elective non-cardiac surgeries.
Not a fit: Patients who are not undergoing surgery or are younger than 65 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing cognitive decline and delirium in older adults after surgery.
How similar studies have performed: Previous research has suggested a link between blood-brain barrier dysfunction and cognitive outcomes, indicating that this approach may yield valuable insights.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Daiello, Lori a — Rhode Island Hospital
- Study coordinator: Daiello, Lori a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.