Understanding how blood and immune cells regenerate in the bone marrow
Official title: A spatial view of hematopoietic regeneration dynamics in the bone marrow
Funded at University of Southern California · NIH-10919070 · Data updated 2026-11-12
This study is looking at how special cells in your bone marrow help make blood and immune cells, especially when there's an injury, and it aims to learn more about how their location affects their job, which could lead to better treatments for blood disorders and cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,630,964 |
| NIH project number | 1R01DK143671-01 |
| Project ID | NIH-10919070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with blood disorders, cancers, or those requiring bone marrow transplants.
✕Less likely to help
Patients with conditions unrelated to blood cell regeneration or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how hematopoietic stem and progenitor cells (HSPCs) in the bone marrow regenerate blood and immune cells. It focuses on how these cells respond to injuries and signals from their environment, which can change based on their location within the bone marrow. By using advanced technologies, the study aims to map the spatial organization of HSPCs and understand how their movement affects their function in producing different types of blood cells. This could provide insights into how to improve treatments for conditions like blood disorders and cancers.
Why it matters
Potential benefit: If successful, this research could lead to better therapies for blood-related diseases and improve outcomes for patients undergoing treatments like bone marrow transplants.
How similar studies have gone: Previous research has shown promising results in understanding hematopoietic stem cell dynamics, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Lu, Rong — University of Southern California
- Study coordinator: Lu, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.