Understanding how bladder wall stiffness affects the feeling of fullness
Official title: Bladder Wall Stiffness Drives Sensation of Fullness
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-10989925 · Data updated 2026-11-12
This study is looking at how the strength and flexibility of the bladder wall affect how we feel when our bladder is full, using special imaging and mouse models to help us understand these processes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $475,639 |
| NIH project number | 5R01DK135696-02 |
| Project ID | NIH-10989925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing bladder dysfunction, including those with overactive or underactive bladder conditions.
✕Less likely to help
Patients with bladder dysfunction caused by known pathologies or injuries may not benefit directly from this research.
What this research studies
This research investigates how the mechanical properties of the bladder wall, such as stiffness and elasticity, influence the sensation of bladder fullness. By using advanced imaging techniques and biomechanical modeling, the study aims to explore the relationship between bladder wall structure and the signals sent to the brain that indicate when it's time to void. The research will involve genetic mouse models to better understand these mechanisms in a controlled environment, free from other bladder pathologies. Ultimately, the goal is to clarify the biological processes that lead to the sensation of fullness in the bladder.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bladder dysfunction, enhancing the quality of life for patients with urinary issues.
How similar studies have gone: While there has been research on bladder dysfunction, this approach focusing on the biomechanics of bladder wall stiffness is relatively novel and untested.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Tykocki, Nathan Roger — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Tykocki, Nathan Roger
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.