Understanding how bladder cancer spreads
Investigating mechanisms of bladder cancer metastasis
This study is looking at how bladder cancer spreads in the body, especially in patients with advanced stages of the disease, using special mouse models to find out what causes this spread and to discover new treatments that might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10931503 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the spread of bladder cancer, particularly focusing on metastatic bladder cancer (mMIBC), which is a leading cause of death in patients. The team has developed advanced genetically-engineered mouse models that mimic human disease, allowing for in-depth study of how bladder cancer metastasizes. By using these models, researchers aim to identify key biological factors that drive metastasis and to discover potential drug treatments that could target these factors effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bladder cancer, particularly those with advanced or metastatic forms of the disease.
Not a fit: Patients with early-stage bladder cancer or those without a diagnosis of bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with metastatic bladder cancer.
How similar studies have performed: Other research has shown promise in using genetically-engineered models to study cancer metastasis, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Abate-Shen, Cory — Columbia University Health Sciences
- Study coordinator: Abate-Shen, Cory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.