Understanding how bladder cancer progresses and resists treatment
Defining Mechanisms of Progression and Treatment Resistance in Localized Bladder Cancer
['FUNDING_R37'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10980536
This study is looking at how bladder cancer can become more serious and aims to find out which genes are involved, so they can create better treatments for patients who don’t respond to current therapies, helping them avoid major surgery.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10980536 on ClinicalTrials.gov |
What this research studies
This research focuses on bladder cancer, particularly how it can progress from a non-invasive to a more dangerous muscle-invasive state. The team aims to identify the genetic factors that contribute to this progression and the resistance to standard treatments like bacillus Calmette-Guérin (BCG) therapy. By analyzing the genetic profiles of patients, they hope to discover new targeted therapies that could effectively treat bladder cancer without the need for radical surgery. This approach is designed to improve outcomes for patients who do not respond well to existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-muscle invasive bladder cancer who are at risk of progression to muscle-invasive disease.
Not a fit: Patients with muscle-invasive bladder cancer who have already undergone radical surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bladder cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Other research has shown promise in targeting genetic factors in cancer treatment, suggesting that this approach could lead to significant advancements in bladder cancer therapy.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIETZAK, EUGENE — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: PIETZAK, EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.