Understanding how biomechanics and genetics affect glaucoma progression
Biomechanical and genetic effects on glaucoma progression
This study is exploring how certain physical and genetic factors affect glaucoma, a condition that can lead to permanent vision loss, by looking at dogs with a specific genetic mutation to help find new ways to protect vision for people with glaucoma.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10838456 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind glaucoma, a leading cause of irreversible vision loss, by focusing on the role of biomechanical factors and genetic mutations. It aims to understand how differences in the biomechanical response of the optic nerve head to intraocular pressure may influence the progression of glaucoma. The study will involve both clinical observations and experimental approaches, particularly looking at dogs with a specific genetic mutation that affects their susceptibility to glaucoma. By identifying these mechanisms, the research seeks to develop new therapeutic strategies that could better preserve vision in glaucoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glaucoma, particularly those who may have genetic predispositions affecting their condition.
Not a fit: Patients with glaucoma who do not have any genetic mutations or biomechanical factors influencing their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve vision preservation in patients with glaucoma.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in glaucoma, but this specific biomechanical approach is relatively novel.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Park, Shin Ae — Purdue University
- Study coordinator: Park, Shin Ae
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.