Understanding how biological molecules change shape and function
Macromolecular Conformational Heterogeneity
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11065467
This study looks at the different shapes of important molecules in our bodies and how those shapes influence their roles, which could help scientists create better medicines, especially for immune-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11065467 on ClinicalTrials.gov |
What this research studies
This research investigates the diverse shapes that biological macromolecules can take and how these shapes affect their functions. By studying the interactions of these molecules with ions and other substances, the research aims to uncover important insights that could aid in drug discovery. The team employs advanced computational modeling techniques to analyze the conformational properties of various biological systems, including RNA and glycoproteins involved in immune responses. This work is crucial for developing new therapeutic strategies and improving existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune responses or cancers that may benefit from targeted therapies.
Not a fit: Patients with conditions unrelated to biological macromolecule function or those not requiring drug interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drugs and therapies by enhancing our understanding of how biological molecules function.
How similar studies have performed: Previous research has shown promise in understanding macromolecular conformational changes, indicating that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACKERELL, ALEXANDER D — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MACKERELL, ALEXANDER D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers