Understanding how biological aging affects multiple sclerosis outcomes and immune function
Official title: Associations of biological aging with outcomes and immune dysregulation in multiple sclerosis
Funded at Ohio State University · NIH-10785765 · Data updated 2026-11-12
This study is looking at how getting older might affect the symptoms of multiple sclerosis (MS) and how the immune system responds, with the goal of finding better ways to treat people with MS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $161,671 |
| NIH project number | 1K23AG084848-01 |
| Project ID | NIH-10785765 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with multiple sclerosis.
✕Less likely to help
Patients with other neurological disorders unrelated to multiple sclerosis may not benefit from this research.
What this research studies
This research investigates the relationship between biological aging and the progression of multiple sclerosis (MS), a chronic condition affecting the central nervous system. It aims to explore how aging processes contribute to the worsening of MS symptoms and the immune system's response. By utilizing established markers of cellular aging and DNA methylation patterns, the study seeks to uncover new insights that could lead to better treatment strategies for MS patients. The research will involve collaboration across various medical specialties to translate findings into clinical practice.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of multiple sclerosis, potentially enhancing treatment outcomes for patients.
How similar studies have gone: While the specific approach of linking biological aging to MS outcomes is novel, related research in aging and chronic diseases has shown promising results.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zhang, Yinan — Ohio State University
- Study coordinator: Zhang, Yinan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.